Survival Analysis and Cox Proportional Hazards Model Reporting in Pediatric Leukemia Studies—a Systematic Review

Abstract Survival (overall, event free, etc.) is the most-used outcome in clinical oncology studies. This study analyzed methodological reporting of survival analysis pediatric leukemia studies, focusing on Cox proportional hazards (PH). We performed a systematic review studies published between 2012 and 2021 five highest-ranking hematology journals. The included had to focus utilize analyses. extracted data how methodology was reported focused modeling whether PH assumption checked. screened 561 103 analysis. crude method Kaplan–Meier, as 96 (94%) applied it. Adjusted 80 (78%) model used 77 (96%) these mentioned 18 (23%) that model. Only nine (12%) stated assessed. noted 10 (13%) with possible violations assumption. Overall, we found need for improvement especially adjusted but checking background not most